diff --git a/Source/Core/Core/Core.cpp b/Source/Core/Core/Core.cpp
index 9ca298a837..5396c8439b 100644
--- a/Source/Core/Core/Core.cpp
+++ b/Source/Core/Core/Core.cpp
@@ -391,9 +391,10 @@ static void CpuThread(const std::optional<std::string>& savestate_path, bool del
   static_cast<void>(IDCache::GetEnvForThread());
 #endif
 
-  const bool fastmem_enabled = Config::Get(Config::MAIN_FASTMEM);
-  if (fastmem_enabled)
-    EMM::InstallExceptionHandler();  // Let's run under memory watch
+  // The JIT need to be able to intercept faults, both for fastmem and for the BLR optimization.
+  const bool exception_handler = EMM::IsExceptionHandlerSupported();
+  if (exception_handler)
+    EMM::InstallExceptionHandler();
 
 #ifdef USE_MEMORYWATCHER
   s_memory_watcher = std::make_unique<MemoryWatcher>();
@@ -441,7 +442,7 @@ static void CpuThread(const std::optional<std::string>& savestate_path, bool del
 
   s_is_started = false;
 
-  if (fastmem_enabled)
+  if (exception_handler)
     EMM::UninstallExceptionHandler();
 
   if (GDBStub::IsActive())
diff --git a/Source/Core/Core/PowerPC/JitCommon/JitBase.cpp b/Source/Core/Core/PowerPC/JitCommon/JitBase.cpp
index 7cba8c7dfb..bcdafd9725 100644
--- a/Source/Core/Core/PowerPC/JitCommon/JitBase.cpp
+++ b/Source/Core/Core/PowerPC/JitCommon/JitBase.cpp
@@ -18,6 +18,7 @@
 #include "Core/Core.h"
 #include "Core/CoreTiming.h"
 #include "Core/HW/CPU.h"
+#include "Core/MemTools.h"
 #include "Core/PowerPC/PPCAnalyst.h"
 #include "Core/PowerPC/PowerPC.h"
 #include "Core/System.h"
@@ -132,7 +133,8 @@ void JitBase::RefreshConfig()
   analyzer.SetDivByZeroExceptionsEnabled(m_enable_div_by_zero_exceptions);
 
   bool any_watchpoints = m_system.GetPowerPC().GetMemChecks().HasAny();
-  jo.fastmem = m_fastmem_enabled && jo.fastmem_arena && (m_ppc_state.msr.DR || !any_watchpoints);
+  jo.fastmem = m_fastmem_enabled && jo.fastmem_arena && (m_ppc_state.msr.DR || !any_watchpoints) &&
+               EMM::IsExceptionHandlerSupported();
   jo.memcheck = m_system.IsMMUMode() || m_system.IsPauseOnPanicMode() || any_watchpoints;
   jo.fp_exceptions = m_enable_float_exceptions;
   jo.div_by_zero_exceptions = m_enable_div_by_zero_exceptions;
@@ -140,7 +142,8 @@ void JitBase::RefreshConfig()
 
 void JitBase::InitBLROptimization()
 {
-  m_enable_blr_optimization = jo.enableBlocklink && m_fastmem_enabled && !m_enable_debugging;
+  m_enable_blr_optimization =
+      jo.enableBlocklink && !m_enable_debugging && EMM::IsExceptionHandlerSupported();
   m_cleanup_after_stackfault = false;
 }