diff --git a/Source/Core/Core/Src/HW/SystemTimers.cpp b/Source/Core/Core/Src/HW/SystemTimers.cpp
index 815fdde2a2..d7bbfc331b 100644
--- a/Source/Core/Core/Src/HW/SystemTimers.cpp
+++ b/Source/Core/Core/Src/HW/SystemTimers.cpp
@@ -113,7 +113,6 @@ int et_AI;
 int et_AudioDMA;
 int et_DSP;
 int et_IPC_HLE;
-int et_FakeGPWD;	// DC watchdog hack
 int et_PatchEngine;	// PatchEngine updates every 1/60th of a second by default
 
 // These are badly educated guesses
@@ -244,11 +243,12 @@ void Init()
 		// AyuanX: TO BE TWEAKED
 		// Now the 1500 is a pure assumption
 		// We need to figure out the real frequency though
-		// PS: When this period is tweaked, the interval
-		// in WII_IPC_HLE_Device_usb.cpp should also be tweaked accordingly
-		// to guarantee WiiMote updates at a fixed 100Hz
-		int interval = SConfig::GetInstance().m_LocalCoreStartupParameter.bDisableWiimoteSpeaker?1250:1500;
-		int fields = SConfig::GetInstance().m_LocalCoreStartupParameter.bVBeam?2:1;
+
+		// FIXME: does Wiimote Speaker support really require a different interval? (issue 4608)
+		const int interval = SConfig::GetInstance().m_LocalCoreStartupParameter.
+				bDisableWiimoteSpeaker ? 1250 : 1500;
+		const int fields = SConfig::GetInstance().m_LocalCoreStartupParameter.
+				bVBeam ? 2 : 1;
 		IPC_HLE_PERIOD = GetTicksPerSecond() / (interval * fields);
 	}
 	else
diff --git a/Source/Core/Core/Src/IPC_HLE/WII_IPC_HLE_Device_usb.cpp b/Source/Core/Core/Src/IPC_HLE/WII_IPC_HLE_Device_usb.cpp
index 61bb376a51..d4491f8972 100644
--- a/Source/Core/Core/Src/IPC_HLE/WII_IPC_HLE_Device_usb.cpp
+++ b/Source/Core/Core/Src/IPC_HLE/WII_IPC_HLE_Device_usb.cpp
@@ -18,6 +18,7 @@
 #include "../Core.h"
 #include "../Debugger/Debugger_SymbolMap.h"
 #include "../Host.h"
+#include "../HW/SystemTimers.h"
 #include "../HW/Wiimote.h"
 #include "../HW/WII_IPC.h"
 #include "WII_IPC_HLE.h"
@@ -495,17 +496,24 @@ u32 CWII_IPC_HLE_Device_usb_oh1_57e_305::Update()
 		}
 	}
 
-	// The Real Wiimote sends report every ~6.66ms.
+	// The Real Wiimote sends report every ~6.66ms (150 Hz).
 	// However, we don't actually reach here at dependable intervals, so we
 	// instead just timeslice in such a way that makes the stack think we have
 	// perfect "radio quality" (WPADGetRadioSensitivity) and yet still have some
 	// idle time.
-	static int wiimote_to_update = 0;
-	const u64 interval = 729000000u / 200; // 5ms behaves well
-	u64 each_wiimote_interval = interval / m_WiiMotes.size();
-	u64 now = CoreTiming::GetTicks();
+	// Somehow, Dolphin's Wiimote Speaker support requires using an update interval
+	// of 5ms (200 Hz) for its output to work.  This increased frequency tends to
+	// fill the ACL queue (even) quicker than it can be processed by Dolphin,
+	// especially during simultaneous requests involving many (emulated) Wiimotes...
+	// Thus, we only use that interval when the option is enabled.  See issue 4608.
+	const u64 interval = SystemTimers::GetTicksPerSecond() / (SConfig::GetInstance().
+			m_LocalCoreStartupParameter.bDisableWiimoteSpeaker ? 150 : 200);
+	const u64 each_wiimote_interval = interval / m_WiiMotes.size();
+	const u64 now = CoreTiming::GetTicks();
+
 	if (now - m_last_ticks > each_wiimote_interval)
 	{
+		static int wiimote_to_update = 0;
 		if (m_WiiMotes[wiimote_to_update].IsConnected())
 		{
 			NetPlay_WiimoteUpdate(wiimote_to_update);
diff --git a/Source/Core/Core/Src/IPC_HLE/WII_IPC_HLE_Device_usb.h b/Source/Core/Core/Src/IPC_HLE/WII_IPC_HLE_Device_usb.h
index 897f3a9e86..6bb381ed6f 100644
--- a/Source/Core/Core/Src/IPC_HLE/WII_IPC_HLE_Device_usb.h
+++ b/Source/Core/Core/Src/IPC_HLE/WII_IPC_HLE_Device_usb.h
@@ -182,10 +182,24 @@ private:
 		{
 			_dbg_assert_msg_(WII_IPC_WIIMOTE,
 				size < m_acl_pkt_size, "acl packet too large for pool");
+
+			const int next_write_ptr = (m_write_ptr + 1) % m_acl_pkts_num;
+			if (next_write_ptr == m_read_ptr)
+			{
+				// Many simultaneous exchanges of ACL packets tend to cause the
+				// 10-packet limit to be exceeded.  Typically, this occurs when
+				// many emulated Wiimotes are requesting connections at once.
+				// See issue 4608 for more info.
+				ERROR_LOG(WII_IPC_WIIMOTE, "ACL queue is full - current packet will be "
+						"dropped! (m_write_ptr(%d) was about to overlap m_read_ptr(%d))",
+						m_write_ptr, m_read_ptr);
+				return;
+			}
+
 			memcpy(m_pool + m_acl_pkt_size * m_write_ptr, data, size);
 			m_info[m_write_ptr].size = size;
 			m_info[m_write_ptr].conn_handle = conn_handle;
-			m_write_ptr = (m_write_ptr + 1) % m_acl_pkts_num;
+			m_write_ptr = next_write_ptr;
 		}
 
 		void WriteToEndpoint(CtrlBuffer& endpoint);