diff --git a/Source/Core/DolphinQt/Config/Graphics/AdvancedWidget.cpp b/Source/Core/DolphinQt/Config/Graphics/AdvancedWidget.cpp
index 32b24440b6..afdedc3ea0 100644
--- a/Source/Core/DolphinQt/Config/Graphics/AdvancedWidget.cpp
+++ b/Source/Core/DolphinQt/Config/Graphics/AdvancedWidget.cpp
@@ -36,6 +36,10 @@ AdvancedWidget::AdvancedWidget(GraphicsWindow* parent)
   connect(&Settings::Instance(), &Settings::EmulationStateChanged, this, [this](Core::State state) {
     OnEmulationStateChanged(state != Core::State::Uninitialized);
   });
+  connect(m_manual_texture_sampling, &QCheckBox::toggled, [this, parent] {
+    SaveSettings();
+    emit parent->UseFastTextureSamplingChanged();
+  });
 
   OnBackendChanged();
   OnEmulationStateChanged(Core::GetState() != Core::State::Uninitialized);
diff --git a/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp b/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
index fac9400186..aa0e3d1d28 100644
--- a/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
+++ b/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
@@ -39,6 +39,10 @@ EnhancementsWidget::EnhancementsWidget(GraphicsWindow* parent) : m_block_save(fa
   AddDescriptions();
   connect(parent, &GraphicsWindow::BackendChanged,
           [this](const QString& backend) { LoadSettings(); });
+  connect(parent, &GraphicsWindow::UseFastTextureSamplingChanged, this,
+          &EnhancementsWidget::LoadSettings);
+  connect(parent, &GraphicsWindow::UseGPUTextureDecodingChanged, this,
+          &EnhancementsWidget::LoadSettings);
 }
 
 constexpr int TEXTURE_FILTERING_DEFAULT = 0;
@@ -307,6 +311,9 @@ void EnhancementsWidget::LoadPPShaders()
 void EnhancementsWidget::LoadSettings()
 {
   m_block_save = true;
+  m_texture_filtering_combo->setEnabled(Config::Get(Config::GFX_HACK_FAST_TEXTURE_SAMPLING));
+  m_arbitrary_mipmap_detection->setEnabled(!Config::Get(Config::GFX_ENABLE_GPU_TEXTURE_DECODING));
+
   // Anti-Aliasing
 
   const u32 aa_selection = Config::Get(Config::GFX_MSAA);
@@ -503,7 +510,8 @@ void EnhancementsWidget::AddDescriptions()
       "that are at oblique viewing angles. Force Nearest and Force Linear override the texture "
       "scaling filter selected by the game.<br><br>Any option except 'Default' will alter the look "
       "of the game's textures and might cause issues in a small number of "
-      "games.<br><br><dolphin_emphasis>If unsure, select 'Default'.</dolphin_emphasis>");
+      "games.<br><br>This option is incompatible with Manual Texture Sampling.<br><br>"
+      "<dolphin_emphasis>If unsure, select 'Default'.</dolphin_emphasis>");
   static const char TR_OUTPUT_RESAMPLING_DESCRIPTION[] =
       QT_TR_NOOP("Affects how the game output is scaled to the window resolution."
                  "<br>The performance mostly depends on the number of samples each method uses."
diff --git a/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h b/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
index 5949a2dda3..97673563b5 100644
--- a/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
+++ b/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
@@ -24,6 +24,8 @@ public:
 
 signals:
   void BackendChanged(const QString& backend);
+  void UseFastTextureSamplingChanged();
+  void UseGPUTextureDecodingChanged();
 
 private:
   void CreateMainLayout();
diff --git a/Source/Core/DolphinQt/Config/Graphics/HacksWidget.cpp b/Source/Core/DolphinQt/Config/Graphics/HacksWidget.cpp
index 9441966f0e..cfdfa866a4 100644
--- a/Source/Core/DolphinQt/Config/Graphics/HacksWidget.cpp
+++ b/Source/Core/DolphinQt/Config/Graphics/HacksWidget.cpp
@@ -31,6 +31,10 @@ HacksWidget::HacksWidget(GraphicsWindow* parent)
   connect(parent, &GraphicsWindow::BackendChanged, this, &HacksWidget::OnBackendChanged);
   OnBackendChanged(QString::fromStdString(Config::Get(Config::MAIN_GFX_BACKEND)));
   connect(&Settings::Instance(), &Settings::ConfigChanged, this, &HacksWidget::LoadSettings);
+  connect(m_gpu_texture_decoding, &QCheckBox::toggled, [this, parent] {
+    SaveSettings();
+    emit parent->UseGPUTextureDecodingChanged();
+  });
 }
 
 void HacksWidget::CreateWidgets()
@@ -264,8 +268,8 @@ void HacksWidget::AddDescriptions()
   static const char TR_GPU_DECODING_DESCRIPTION[] = QT_TR_NOOP(
       "Enables texture decoding using the GPU instead of the CPU.<br><br>This may result in "
       "performance gains in some scenarios, or on systems where the CPU is the "
-      "bottleneck.<br><br><dolphin_emphasis>If unsure, leave this "
-      "unchecked.</dolphin_emphasis>");
+      "bottleneck.<br><br>This option is incompatible with Arbitrary Mipmap Detection.<br><br>"
+      "<dolphin_emphasis>If unsure, leave this unchecked.</dolphin_emphasis>");
   static const char TR_FAST_DEPTH_CALC_DESCRIPTION[] = QT_TR_NOOP(
       "Uses a less accurate algorithm to calculate depth values.<br><br>Causes issues in a few "
       "games, but can result in a decent speed increase depending on the game and/or "