diff --git a/Source/Core/VideoCommon/NativeVertexFormat.h b/Source/Core/VideoCommon/NativeVertexFormat.h
index 89f3a06db5..c2761c9514 100644
--- a/Source/Core/VideoCommon/NativeVertexFormat.h
+++ b/Source/Core/VideoCommon/NativeVertexFormat.h
@@ -63,6 +63,9 @@ struct PortableVertexDeclaration
   std::array<AttributeFormat, 8> texcoords;
   AttributeFormat posmtx;
 
+  // Make sure we initialize padding to 0 since padding is included in the == memcmp
+  PortableVertexDeclaration() { memset(this, 0, sizeof(*this)); }
+
   inline bool operator<(const PortableVertexDeclaration& b) const
   {
     return memcmp(this, &b, sizeof(PortableVertexDeclaration)) < 0;
@@ -73,6 +76,9 @@ struct PortableVertexDeclaration
   }
 };
 
+static_assert(std::is_trivially_copyable_v<PortableVertexDeclaration>,
+              "Make sure we can memset-initialize");
+
 namespace std
 {
 template <>