diff --git a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
index 0a82d6451f..1dc02e689a 100644
--- a/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
+++ b/Source/Core/VideoBackends/Vulkan/VulkanContext.cpp
@@ -377,6 +377,10 @@ void VulkanContext::PopulateBackendInfoFeatures(VideoConfig* config, VkPhysicalD
     // We will use shader blending, so disable hardware dual source blending.
     config->backend_info.bSupportsDualSourceBlend = false;
   }
+
+  // Dynamic sampler indexing locks up Intel GPUs on MoltenVK/Metal
+  if (DriverDetails::HasBug(DriverDetails::BUG_BROKEN_DYNAMIC_SAMPLER_INDEXING))
+    config->backend_info.bSupportsDynamicSamplerIndexing = false;
 }
 
 void VulkanContext::PopulateBackendInfoMultisampleModes(
diff --git a/Source/Core/VideoCommon/DriverDetails.cpp b/Source/Core/VideoCommon/DriverDetails.cpp
index 6d7749c949..35e0808469 100644
--- a/Source/Core/VideoCommon/DriverDetails.cpp
+++ b/Source/Core/VideoCommon/DriverDetails.cpp
@@ -142,6 +142,8 @@ constexpr BugInfo m_known_bugs[] = {
      -1.0, -1.0, true},
     {API_VULKAN, OS_OSX, VENDOR_APPLE, DRIVER_PORTABILITY, Family::UNKNOWN,
      BUG_BROKEN_DISCARD_WITH_EARLY_Z, -1.0, -1.0, true},
+    {API_VULKAN, OS_OSX, VENDOR_INTEL, DRIVER_PORTABILITY, Family::UNKNOWN,
+     BUG_BROKEN_DYNAMIC_SAMPLER_INDEXING, -1.0, -1.0, true},
 };
 
 static std::map<Bug, BugInfo> m_bugs;
diff --git a/Source/Core/VideoCommon/DriverDetails.h b/Source/Core/VideoCommon/DriverDetails.h
index 70c39450c9..80159495ee 100644
--- a/Source/Core/VideoCommon/DriverDetails.h
+++ b/Source/Core/VideoCommon/DriverDetails.h
@@ -328,6 +328,12 @@ enum Bug
   // Started version: -1
   // Ended version: -1
   BUG_BROKEN_DISCARD_WITH_EARLY_Z,
+
+  // BUG: Using dynamic sampler indexing locks up the GPU
+  // Affected devices: Intel (macOS Metal)
+  // Started version: -1
+  // Ended version: -1
+  BUG_BROKEN_DYNAMIC_SAMPLER_INDEXING,
 };
 
 // Initializes our internal vendor, device family, and driver version