diff --git a/Source/Core/VideoBackends/D3D/TextureCache.h b/Source/Core/VideoBackends/D3D/TextureCache.h
index 6045d3f7db..79cd8145a8 100644
--- a/Source/Core/VideoBackends/D3D/TextureCache.h
+++ b/Source/Core/VideoBackends/D3D/TextureCache.h
@@ -43,6 +43,9 @@ private:
 
 	TCacheEntryBase* CreateRenderTargetTexture(unsigned int scaled_tex_w, unsigned int scaled_tex_h) override;
 	u64 EncodeToRamFromTexture(u32 address, void* source_texture, u32 SourceW, u32 SourceH, bool bFromZBuffer, bool bIsIntensityFmt, u32 copyfmt, int bScaleByHalf, const EFBRectangle& source) {return 0;};
+
+	void CompileShaders() override { }
+	void DeleteShaders() override { }
 };
 
 }
diff --git a/Source/Core/VideoBackends/OGL/TextureCache.cpp b/Source/Core/VideoBackends/OGL/TextureCache.cpp
index 3c2661b043..547a527818 100644
--- a/Source/Core/VideoBackends/OGL/TextureCache.cpp
+++ b/Source/Core/VideoBackends/OGL/TextureCache.cpp
@@ -318,6 +318,32 @@ void TextureCache::TCacheEntry::FromRenderTarget(u32 dstAddr, unsigned int dstFo
 }
 
 TextureCache::TextureCache()
+{
+	CompileShaders();
+
+	s_ActiveTexture = -1;
+	for (auto& gtex : s_Textures)
+		gtex = -1;
+}
+
+
+TextureCache::~TextureCache()
+{
+	DeleteShaders();
+}
+
+void TextureCache::DisableStage(unsigned int stage)
+{
+}
+
+void TextureCache::SetStage()
+{
+	// -1 is the initial value as we don't know which texture should be bound
+	if (s_ActiveTexture != (u32)-1)
+		glActiveTexture(GL_TEXTURE0 + s_ActiveTexture);
+}
+
+void TextureCache::CompileShaders()
 {
 	const char *pColorMatrixProg =
 		"SAMPLER_BINDING(9) uniform sampler2DArray samp9;\n"
@@ -414,28 +440,12 @@ TextureCache::TextureCache()
 
 	s_ColorCopyPositionUniform = glGetUniformLocation(s_ColorMatrixProgram.glprogid, "copy_position");
 	s_DepthCopyPositionUniform = glGetUniformLocation(s_DepthMatrixProgram.glprogid, "copy_position");
-
-	s_ActiveTexture = -1;
-	for (auto& gtex : s_Textures)
-		gtex = -1;
 }
 
-
-TextureCache::~TextureCache()
+void TextureCache::DeleteShaders()
 {
 	s_ColorMatrixProgram.Destroy();
 	s_DepthMatrixProgram.Destroy();
 }
 
-void TextureCache::DisableStage(unsigned int stage)
-{
-}
-
-void TextureCache::SetStage ()
-{
-	// -1 is the initial value as we don't know which texture should be bound
-	if (s_ActiveTexture != (u32)-1)
-		glActiveTexture(GL_TEXTURE0 + s_ActiveTexture);
-}
-
 }
diff --git a/Source/Core/VideoBackends/OGL/TextureCache.h b/Source/Core/VideoBackends/OGL/TextureCache.h
index e1e2ec694c..f8d181e8e1 100644
--- a/Source/Core/VideoBackends/OGL/TextureCache.h
+++ b/Source/Core/VideoBackends/OGL/TextureCache.h
@@ -57,6 +57,9 @@ private:
 		unsigned int expanded_width, unsigned int tex_levels, PC_TexFormat pcfmt) override;
 
 	TCacheEntryBase* CreateRenderTargetTexture(unsigned int scaled_tex_w, unsigned int scaled_tex_h) override;
+
+	void CompileShaders() override;
+	void DeleteShaders() override;
 };
 
 bool SaveTexture(const std::string& filename, u32 textarget, u32 tex, int virtual_width, int virtual_height, unsigned int level);
diff --git a/Source/Core/VideoCommon/TextureCacheBase.cpp b/Source/Core/VideoCommon/TextureCacheBase.cpp
index 4037a7470b..651bb90708 100644
--- a/Source/Core/VideoCommon/TextureCacheBase.cpp
+++ b/Source/Core/VideoCommon/TextureCacheBase.cpp
@@ -115,6 +115,12 @@ void TextureCache::OnConfigChanged(VideoConfig& config)
 		{
 			g_texture_cache->ClearRenderTargets();
 		}
+
+		if ((config.iStereoMode > 0) != backup_config.s_stereo_3d)
+		{
+			g_texture_cache->DeleteShaders();
+			g_texture_cache->CompileShaders();
+		}
 	}
 
 	backup_config.s_colorsamples = config.iSafeTextureCache_ColorSamples;
@@ -126,6 +132,7 @@ void TextureCache::OnConfigChanged(VideoConfig& config)
 	backup_config.s_texfmt_overlay_center = config.bTexFmtOverlayCenter;
 	backup_config.s_hires_textures = config.bHiresTextures;
 	backup_config.s_copy_cache_enable = config.bEFBCopyCacheEnable;
+	backup_config.s_stereo_3d = config.iStereoMode > 0;
 }
 
 void TextureCache::Cleanup()
diff --git a/Source/Core/VideoCommon/TextureCacheBase.h b/Source/Core/VideoCommon/TextureCacheBase.h
index 77bdec14fa..7fc3e49a2f 100644
--- a/Source/Core/VideoCommon/TextureCacheBase.h
+++ b/Source/Core/VideoCommon/TextureCacheBase.h
@@ -102,6 +102,9 @@ public:
 		unsigned int expanded_width, unsigned int tex_levels, PC_TexFormat pcfmt) = 0;
 	virtual TCacheEntryBase* CreateRenderTargetTexture(unsigned int scaled_tex_w, unsigned int scaled_tex_h) = 0;
 
+	virtual void CompileShaders() = 0; // currently only implemented by OGL
+	virtual void DeleteShaders() = 0; // currently only implemented by OGL
+
 	static TCacheEntryBase* Load(unsigned int stage, u32 address, unsigned int width, unsigned int height,
 		int format, unsigned int tlutaddr, int tlutfmt, bool use_mipmaps, unsigned int maxlevel, bool from_tmem);
 	static void CopyRenderTargetToTexture(u32 dstAddr, unsigned int dstFormat, PEControl::PixelFormat srcFormat,
@@ -141,6 +144,7 @@ private:
 		bool s_texfmt_overlay_center;
 		bool s_hires_textures;
 		bool s_copy_cache_enable;
+		bool s_stereo_3d;
 	} backup_config;
 };