diff --git a/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/NativeLibrary.java b/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/NativeLibrary.java
index 1cdd9fa473..63d40d5a91 100644
--- a/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/NativeLibrary.java
+++ b/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/NativeLibrary.java
@@ -391,6 +391,11 @@ public final class NativeLibrary
    */
   public static native boolean IsUninitialized();
 
+  /**
+   * Re-initialize software JitBlock profiling data
+   */
+  public static native void WipeJitBlockProfilingData();
+
   /**
    * Writes out the JitBlock Cache log dump
    */
diff --git a/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/features/settings/ui/SettingsFragmentPresenter.kt b/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/features/settings/ui/SettingsFragmentPresenter.kt
index 7404b396fa..2af2202599 100644
--- a/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/features/settings/ui/SettingsFragmentPresenter.kt
+++ b/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/features/settings/ui/SettingsFragmentPresenter.kt
@@ -2013,6 +2013,16 @@ class SettingsFragmentPresenter(
                 0
            )
         )
+        sl.add(
+            RunRunnable(
+                context,
+                R.string.debug_jit_wipe_block_profiling_data,
+                0,
+                R.string.debug_jit_wipe_block_profiling_data_alert,
+                0,
+                true
+            ) { NativeLibrary.WipeJitBlockProfilingData() }
+        )
         sl.add(
             RunRunnable(
                 context,
diff --git a/Source/Android/app/src/main/res/values/strings.xml b/Source/Android/app/src/main/res/values/strings.xml
index 8d1f9db297..aacc57a3be 100644
--- a/Source/Android/app/src/main/res/values/strings.xml
+++ b/Source/Android/app/src/main/res/values/strings.xml
@@ -412,6 +412,8 @@
     <string name="debug_large_entry_points_map">Disable Large Entry Points Map</string>
     <string name="debug_jit_profiling_header">Jit Profiling</string>
     <string name="debug_jit_enable_block_profiling">Enable Jit Block Profiling</string>
+    <string name="debug_jit_wipe_block_profiling_data">Wipe Jit Block Profiling Data</string>
+    <string name="debug_jit_wipe_block_profiling_data_alert">Re-initialize JIT block profiling data?</string>
     <string name="debug_jit_write_block_log_dump">Write Jit Block Log Dump</string>
     <string name="debug_jit_header">Jit</string>
     <string name="debug_jitoff">Jit Disabled</string>
diff --git a/Source/Android/jni/MainAndroid.cpp b/Source/Android/jni/MainAndroid.cpp
index 270dad9ed3..f0a74986f6 100644
--- a/Source/Android/jni/MainAndroid.cpp
+++ b/Source/Android/jni/MainAndroid.cpp
@@ -410,6 +410,22 @@ JNIEXPORT jint JNICALL Java_org_dolphinemu_dolphinemu_NativeLibrary_GetMaxLogLev
   return static_cast<jint>(Common::Log::MAX_LOGLEVEL);
 }
 
+JNIEXPORT void JNICALL Java_org_dolphinemu_dolphinemu_NativeLibrary_WipeJitBlockProfilingData(
+    JNIEnv* env, jclass native_library_class)
+{
+  HostThreadLock guard;
+  auto& system = Core::System::GetInstance();
+  auto& jit_interface = system.GetJitInterface();
+  const Core::CPUThreadGuard cpu_guard(system);
+  if (jit_interface.GetCore() == nullptr)
+  {
+    env->CallStaticVoidMethod(native_library_class, IDCache::GetDisplayToastMsg(),
+                              ToJString(env, Common::GetStringT("JIT is not active")), JNI_FALSE);
+    return;
+  }
+  jit_interface.WipeBlockProfilingData(cpu_guard);
+}
+
 JNIEXPORT void JNICALL Java_org_dolphinemu_dolphinemu_NativeLibrary_WriteJitBlockLogDump(
     JNIEnv* env, jclass native_library_class)
 {
diff --git a/Source/Core/Core/PowerPC/JitCommon/JitCache.cpp b/Source/Core/Core/PowerPC/JitCommon/JitCache.cpp
index 890e9975a4..62be327460 100644
--- a/Source/Core/Core/PowerPC/JitCommon/JitCache.cpp
+++ b/Source/Core/Core/PowerPC/JitCommon/JitCache.cpp
@@ -117,6 +117,15 @@ void JitBaseBlockCache::RunOnBlocks(const Core::CPUThreadGuard&,
     f(e.second);
 }
 
+void JitBaseBlockCache::WipeBlockProfilingData(const Core::CPUThreadGuard&)
+{
+  for (const auto& kv : block_map)
+  {
+    if (JitBlock::ProfileData* const profile_data = kv.second.profile_data.get())
+      *profile_data = {};
+  }
+}
+
 JitBlock* JitBaseBlockCache::AllocateBlock(u32 em_address)
 {
   const u32 physical_address = m_jit.m_mmu.JitCache_TranslateAddress(em_address).address;
diff --git a/Source/Core/Core/PowerPC/JitCommon/JitCache.h b/Source/Core/Core/PowerPC/JitCommon/JitCache.h
index 15e8c99e43..9539c15815 100644
--- a/Source/Core/Core/PowerPC/JitCommon/JitCache.h
+++ b/Source/Core/Core/PowerPC/JitCommon/JitCache.h
@@ -161,6 +161,7 @@ public:
   u8** GetEntryPoints();
   JitBlock** GetFastBlockMapFallback();
   void RunOnBlocks(const Core::CPUThreadGuard& guard, std::function<void(const JitBlock&)> f) const;
+  void WipeBlockProfilingData(const Core::CPUThreadGuard& guard);
 
   JitBlock* AllocateBlock(u32 em_address);
   void FinalizeBlock(JitBlock& block, bool block_link, const std::set<u32>& physical_addresses);
diff --git a/Source/Core/Core/PowerPC/JitInterface.cpp b/Source/Core/Core/PowerPC/JitInterface.cpp
index 7e0e281998..df128bb496 100644
--- a/Source/Core/Core/PowerPC/JitInterface.cpp
+++ b/Source/Core/Core/PowerPC/JitInterface.cpp
@@ -182,6 +182,12 @@ void JitInterface::JitBlockLogDump(const Core::CPUThreadGuard& guard, std::FILE*
   }
 }
 
+void JitInterface::WipeBlockProfilingData(const Core::CPUThreadGuard& guard)
+{
+  if (m_jit)
+    m_jit->GetBlockCache()->WipeBlockProfilingData(guard);
+}
+
 std::variant<JitInterface::GetHostCodeError, JitInterface::GetHostCodeResult>
 JitInterface::GetHostCode(u32 address) const
 {
diff --git a/Source/Core/Core/PowerPC/JitInterface.h b/Source/Core/Core/PowerPC/JitInterface.h
index 17d0796bfd..0abf47eccb 100644
--- a/Source/Core/Core/PowerPC/JitInterface.h
+++ b/Source/Core/Core/PowerPC/JitInterface.h
@@ -57,6 +57,7 @@ public:
 
   void UpdateMembase();
   void JitBlockLogDump(const Core::CPUThreadGuard& guard, std::FILE* file) const;
+  void WipeBlockProfilingData(const Core::CPUThreadGuard& guard);
   std::variant<GetHostCodeError, GetHostCodeResult> GetHostCode(u32 address) const;
 
   // Memory Utilities
diff --git a/Source/Core/DolphinQt/MenuBar.cpp b/Source/Core/DolphinQt/MenuBar.cpp
index 74f3f45e45..6170fa9ada 100644
--- a/Source/Core/DolphinQt/MenuBar.cpp
+++ b/Source/Core/DolphinQt/MenuBar.cpp
@@ -155,7 +155,8 @@ void MenuBar::OnEmulationStateChanged(Core::State state)
   m_jit_clear_cache->setEnabled(running);
   m_jit_log_coverage->setEnabled(!running);
   m_jit_search_instruction->setEnabled(running);
-  m_jit_write_cache_log_dump->setEnabled(running && jit_exists);
+  m_jit_wipe_profiling_data->setEnabled(jit_exists);
+  m_jit_write_cache_log_dump->setEnabled(jit_exists);
 
   // Symbols
   m_symbols->setEnabled(running);
@@ -196,6 +197,12 @@ void MenuBar::OnDebugModeToggled(bool enabled)
   }
 }
 
+void MenuBar::OnWipeJitBlockProfilingData()
+{
+  auto& system = Core::System::GetInstance();
+  system.GetJitInterface().WipeBlockProfilingData(Core::CPUThreadGuard{system});
+}
+
 void MenuBar::OnWriteJitBlockLogDump()
 {
   const std::string filename = fmt::format("{}{}.txt", File::GetUserPath(D_DUMPDEBUG_JITBLOCKS_IDX),
@@ -922,6 +929,8 @@ void MenuBar::AddJITMenu()
   connect(m_jit_profile_blocks, &QAction::toggled, [](bool enabled) {
     Config::SetBaseOrCurrent(Config::MAIN_DEBUG_JIT_ENABLE_PROFILING, enabled);
   });
+  m_jit_wipe_profiling_data = m_jit->addAction(tr("Wipe JIT Block Profiling Data"), this,
+                                               &MenuBar::OnWipeJitBlockProfilingData);
   m_jit_write_cache_log_dump =
       m_jit->addAction(tr("Write JIT Block Log Dump"), this, &MenuBar::OnWriteJitBlockLogDump);
 
diff --git a/Source/Core/DolphinQt/MenuBar.h b/Source/Core/DolphinQt/MenuBar.h
index 38bc164dc6..4ccc8df819 100644
--- a/Source/Core/DolphinQt/MenuBar.h
+++ b/Source/Core/DolphinQt/MenuBar.h
@@ -185,6 +185,7 @@ private:
   void OnRecordingStatusChanged(bool recording);
   void OnReadOnlyModeChanged(bool read_only);
   void OnDebugModeToggled(bool enabled);
+  void OnWipeJitBlockProfilingData();
   void OnWriteJitBlockLogDump();
 
   QString GetSignatureSelector() const;
@@ -270,6 +271,7 @@ private:
   QAction* m_jit_log_coverage;
   QAction* m_jit_search_instruction;
   QAction* m_jit_profile_blocks;
+  QAction* m_jit_wipe_profiling_data;
   QAction* m_jit_write_cache_log_dump;
   QAction* m_jit_off;
   QAction* m_jit_loadstore_off;